• 
  Boca Juniors – Central

  12 September

• 
  Defensa y Justicia – Gimnasia

  11 September

• 
  Newell`s Old Boys – Velez

  11 September

• 
  Manchester Utd – Sabah

  10 September

• 
  Bayern – Bodoe/Glimt

  10 September

• 
  Como – RB Leipzig

  10 September

• 
  Slavia Prague – Lens

  10 September

• 
  Fenerbahce – Roma

  10 September

• 
  PSV – Shakhtar Donetsk

  10 September

• 
  Santa Fe – Deportes

  12 September

• 
  Jaguares de Cordoba – Fortaleza

  12 September

• 
  Millonarios – Deportivo

  11 September

• 
  Rennes – Marseille

  11 September

• 
  Mainz 05 – Eintracht

  12 September

• 
  Freiburg – Borussia M

  12 September

• 
  Augsburg – Leverkusen

  12 September

• 
  Hoffenheim – Stuttgart

  12 September

• 
  Dortmund – Paderborn

  12 September

• 
  Union Berlin – Schalke

  11 September

• 
  Genoa – Frosinone

  12 September

• 
  Venezia – Fiorentina

  11 September

• 
  Kyoto Sanga – Kashiwa

  11 September

• 
  Vissel Kobe – Kashima

  11 September

• 
  CSKA – Admiral

  11 September

• 
  Ak Bars – Metallurg Mg

  11 September

• 
  Neftekhimik – Avtomobilist

  11 September

• 
  Lada Tl – Torpedo NN

  11 September

• 
  Spartak M – SKA

  10 September

• 
  Dinamo Mn – Kunlun RS

  10 September

• 
  Tijuana – Queretaro

  12 September

• 
  Atlante – Pachuca

  12 September

• 
  Necaxa – Puebla

  12 September

• 
  Pumas – Leon

  11 September

• 
  AZ – Willem II

  11 September

• 
  Estrela – Braga

  10 September

• 
  Miercurea Ciuc – Dinamo

  11 September

• 
  Farul – UTA Arad

  11 September

• 
  Krylia Sovetov – Rodina

  11 September

• 
  Racing – Alaves

  12 September

• 
  Sevilla – Valencia

  11 September

• 
  LNZ Cherkasy – Obolon

  12 September

• 
  Kolos – Karpaty

  11 September

• 
  MOIK – Simal

  11 September

• 
  Imisli – Neftchi

  11 September

• 
  Dinamo Minsk Res – Orsha

  11 September

• 
  Bordeaux – Adler

  11 September

• 
  Fribourg – Plzen

  11 September

• 
  Eisbaeren Berlin – Graz

  11 September

• 
  Rogle – Salzburg

  11 September

• 
  Vaxjoe – Tappara

  11 September