• 
  Manchester Utd – Sabah

  10 September

• 
  Bayern – Bodoe/Glimt

  10 September

• 
  Como – RB Leipzig

  10 September

• 
  Slavia Prague – Lens

  10 September

• 
  Fenerbahce – Roma

  10 September

• 
  PSV – Shakhtar Donetsk

  10 September

• 
  Millonarios – Deportivo

  11 September

• 
  Rennes – Marseille

  11 September

• 
  Venezia – Fiorentina

  11 September

• 
  Kyoto Sanga – Kashiwa

  11 September

• 
  Vissel Kobe – Kashima

  11 September

• 
  Lada Tl – Torpedo NN

  11 September

• 
  Spartak M – SKA

  10 September

• 
  Dinamo Mn – Kunlun RS

  10 September

• 
  Lokomotiv – Severstal

  10 September

• 
  Avangard – Sochi

  10 September

• 
  Sibir – Amur

  10 September

• 
  Pumas – Leon

  11 September

• 
  Estrela – Braga

  10 September

• 
  Miercurea Ciuc – Dinamo

  11 September

• 
  Farul – UTA Arad

  11 September

• 
  Krylia Sovetov – Rodina

  11 September

• 
  Sevilla – Valencia

  11 September

• 
  Kolos – Karpaty

  11 September

• 
  Vancouver – LA Galaxy

  10 September

• 
  Portland Timbers – St

  10 September

• 
  Los Angeles – NY

  10 September

• 
  San Diego – San Jose

  10 September

• 
  Austin – Colorado Rapids

  10 September

• 
  Minnesota Utd – Dallas

  10 September

• 
  Houston Dynamo – Real

  10 September

• 
  Chicago Fire – Inter

  10 September

• 
  New York City – New

  10 September

• 
  Philadelphia – Cincinnati

  10 September

• 
  Montreal – Charlotte

  10 September

• 
  DC United – Columbus

  10 September

• 
  Atlanta Utd – Orlando

  10 September

• 
  Toronto – Nashville

  10 September

• 
  MOIK – Simal

  11 September

• 
  Sabail – Asta

  10 September

• 
  Zaqatala – Baku Sporting

  10 September

• 
  Imisli – Neftchi

  11 September

• 
  Dinamo Minsk Res – Orsha

  11 September

• 
  Inter Toronto – Pacific

  10 September

• 
  Koelner Haie – Frolunda

  10 September

• 
  Storhamar – Klagenfurt

  10 September

• 
  Skelleftea – Geneva

  10 September

• 
  Tychy – Davos

  10 September

• 
  Saipa – Dynamo Pardubice

  10 September

• 
  KooKoo – Nitra

  10 September