• 
  Boca Juniors – Central

  12 September

• 
  Defensa y Justicia – Gimnasia

  11 September

• 
  Newell`s Old Boys – Velez

  11 September

• 
  Manchester Utd – Sabah

  10 September

• 
  Bayern – Bodoe/Glimt

  10 September

• 
  Como – RB Leipzig

  10 September

• 
  Slavia Prag – Lens

  10 September

• 
  Mainz 05 – Eintracht

  12 September

• 
  Freiburg – Borussia M

  12 September

• 
  Augsburg – Leverkusen

  12 September

• 
  Hoffenheim – Stuttgart

  12 September

• 
  Dortmund – Paderborn

  12 September

• 
  Union Berlin – Schalke

  11 September

• 
  Liverpool – Fulham

  12 September

• 
  Chelsea – Hull City

  12 September

• 
  Aston Villa – Nottingham

  12 September

• 
  Crystal Palace – Ipswich

  12 September

• 
  Bournemouth – Brentford

  12 September

• 
  Rennes – Marseille

  11 September

• 
  Genua – Frosinone

  12 September

• 
  Venedig – Florenz

  11 September

• 
  Kyoto Sanga – Kashiwa

  11 September

• 
  Vissel Kobe – Kashima

  11 September

• 
  Sotschi – SKA

  12 September

• 
  Barys – Amur

  12 September

• 
  ZSKA – Admiral

  11 September

• 
  Ak Bars – Metallurg Mg

  11 September

• 
  Neftechimik – Awtomobilist

  11 September

• 
  Lada Tl – Torpedo NN

  11 September

• 
  Santa Fe – Deportes

  12 September

• 
  Jaguares de Cordoba – Fortaleza

  12 September

• 
  Millonarios – Deportivo

  11 September

• 
  Tijuana – Queretaro

  12 September

• 
  Atlante – Pachuca

  12 September

• 
  Necaxa – Puebla

  12 September

• 
  Pumas – Leon

  11 September

• 
  AZ – Willem II

  11 September

• 
  Estrela – Braga

  10 September

• 
  Miercurea Ciuc – Dinamo

  11 September

• 
  Farul – UTA Arad

  11 September

• 
  Zenit – Lokomotive M

  12 September

• 
  Fakel – Baltika

  12 September

• 
  Krylja Sowetow – Rodina

  11 September

• 
  Osasuna – Espanyol

  12 September

• 
  Racing – Alaves

  12 September

• 
  Sevilla – Valencia

  11 September

• 
  LNZ Tscherkassy – Obolon

  12 September

• 
  Kolos – Karpaty

  11 September

• 
  MOIK – Simal

  11 September

• 
  Imisli – Neftchi

  11 September