• 
  Union – Instituto

  8 September

• 
  Barracas Central – Argentinos

  7 September

• 
  Racing – Atletico

  7 September

• 
  River Plate – Independiente

  6 September

• 
  Vitoria-BA – Gremio-RS

  8 September

• 
  Corinthians – Chapecoense

  6 September

• 
  Botafogo-RJ – Palmeiras

  6 September

• 
  Real Madrid – Inter

  8 September

• 
  AEK – LASK

  8 September

• 
  Brügge – Aston Villa

  8 September

• 
  Deportes – Cobresal

  8 September

• 
  Palestino – Univ

  6 September

• 
  Orense – Guayaquil City

  8 September

• 
  Mushuc Runa – Leones

  8 September

• 
  Emelec – Manta

  8 September

• 
  Aucas – Barcelona SC

  7 September

• 
  CD Cuenca – Libertad

  7 September

• 
  Asteras – Iraklis

  7 September

• 
  Udinese – Lazio

  7 September

• 
  Cagliari – Lecce

  7 September

• 
  Lokomotive – Kunlun RS

  8 September

• 
  Neftechimik – Sotschi

  8 September

• 
  Metallurg Mg – Amur

  8 September

• 
  Ak Bars – Admiral

  7 September

• 
  ZSKA – Spartak M

  7 September

• 
  SKA – Dynamo M

  7 September

• 
  Dinamo Mn – Torpedo NN

  7 September

• 
  Sewerstal – Lada Tl

  7 September

• 
  Barys – Sibir

  7 September

• 
  Awtomobilist – Traktor

  7 September

• 
  Avangard – Salawat

  7 September

• 
  Llaneros – Deportes

  8 September

• 
  Deportivo – Millonarios

  7 September

• 
  Cruz Azul – Santos

  7 September

• 
  Utrecht – Go

  8 September

• 
  Estoril Praia – Arouca

  7 September

• 
  U Craiova – U Cluj

  7 September

• 
  Voluntari – Arges

  7 September

• 
  Rubin – Achmat

  7 September

• 
  Elche – Real Sociedad

  7 September

• 
  Getafe – Celta

  7 September

• 
  Rizespor – Alanyaspor

  7 September

• 
  Göztepe – Gaziantep

  7 September

• 
  Albion – Progreso

  7 September

• 
  Liverpool M – Boston

  6 September

• 
  Dunaw – Slawia Sofia

  7 September

• 
  Wetzlar – Eisenach

  7 September

• 
  Bromley – AFC Wimbledon

  7 September

• 
  Palermo – Sampdoria

  7 September

• 
  Trient – Lecco

  7 September