• 
  Sporting – Galatasaray

  9 September

• 
  Liverpool – Atletico

  9 September

• 
  PSG – Slovan Bratislava

  9 September

• 
  Napoli – Arsenal

  9 September

• 
  Barcelona – Feyenoord

  9 September

• 
  Stuttgart – Viking

  9 September

• 
  Real Madrid RM – Inter

  8 September

• 
  Lille – Real Betis

  8 September

• 
  Dortmund – Villarreal

  8 September

• 
  Porto – Manchester City

  8 September

• 
  AEK – LASK

  8 September

• 
  Brugge – Aston Villa

  8 September

• 
  CSKA – Torpedo NN

  9 September

• 
  SKA – Lada Tl

  9 September

• 
  Dynamo Msk – Admiral

  9 September

• 
  Ak Bars – Traktor

  9 September

• 
  Barys – Salavat Yulaev

  9 September

• 
  Lokomotiv – Kunlun RS

  8 September

• 
  Neftekhimik – Sochi

  8 September

• 
  Metallurg Mg – Amur

  8 September

• 
  Utrecht – Go

  8 September

• 
  Austin – Colorado Rapids

  10 September

• 
  Minnesota Utd – Dallas

  10 September

• 
  Houston Dynamo – Real

  10 September

• 
  Chicago Fire – Inter

  10 September

• 
  New York City – New

  10 September

• 
  Philadelphia – Cincinnati

  10 September

• 
  Montreal – Charlotte

  10 September

• 
  DC United – Columbus

  10 September

• 
  Atlanta Utd – Orlando

  10 September

• 
  Toronto – Nashville

  10 September

• 
  Sahdag – Karvan

  9 September

• 
  Inter Toronto – Pacific

  10 September

• 
  Deportivo Pasto – Ind

  10 September

• 
  Once Caldas – Alianza

  10 September

• 
  America de Cali – Deportivo

  10 September

• 
  Real Cundinamarca – Inter

  10 September

• 
  Broki – Violette

  10 September

• 
  Portmore United – Mount

  10 September

• 
  Estudiantes – Corinthians

  10 September

• 
  Palmeiras – LDU Quito

  9 September

• 
  Fluminense – Atletico

  8 September

• 
  Santos-SP – Atletico-MG

  9 September

• 
  Boca Juniors – Sao Paolo

  9 September

• 
  Santa Fe – Vasco de Gama

  8 September

• 
  Segesta – Osijek

  9 September

• 
  Bedem – Dinamo Zagreb

  9 September

• 
  Magdeburg – Kolstad

  9 September

• 
  Barcelona – Skanderborg

  9 September

• 
  Nantes – Wisla Plock

  9 September