• 
  Boca Juniors – Lanus

  29 August

• 
  Union – Sarmiento

  28 August

• 
  Cobresal – Palestino

  28 August

• 
  Inter de Bogota – Deportivo

  28 August

• 
  Once Caldas – Deportes

  28 August

• 
  Tottenham – Newcastle

  29 August

• 
  Bournemouth – Everton

  29 August

• 
  Coventry City – Hull

  29 August

• 
  Liverpool – Nottingham

  29 August

• 
  Crystal Palace – Manchester

  28 August

• 
  Strasbourg – Lens

  29 August

• 
  Lille – PSG

  28 August

• 
  Dortmund – Hamburg

  29 August

• 
  Elversberg – Leverkusen

  29 August

• 
  RB Leipzig – Borussia M

  29 August

• 
  Union Berlin – Eintracht

  29 August

• 
  Cologne – Hoffenheim

  29 August

• 
  Mainz 05 – Paderborn

  29 August

• 
  Bayern – Stuttgart

  28 August

• 
  Monza – Udinese

  29 August

• 
  Fiorentina – Frosinone

  29 August

• 
  Sassuolo – Torino

  29 August

• 
  Milan – Venezia

  28 August

• 
  Atlante – Leon

  29 August

• 
  Necaxa – Cruz Azul

  29 August

• 
  Groningen – Fortuna

  28 August

• 
  Viseu – Porto

  29 August

• 
  Alverca – Santa Clara

  29 August

• 
  Arouca – Maritimo

  29 August

• 
  Rio Ave – Sporting

  28 August

• 
  Corvinul – Dinamo

  29 August

• 
  Arges Pitesti – Sepsi

  29 August

• 
  Miercurea Ciuc – CFR

  29 August

• 
  U Cluj – Petrolul

  28 August

• 
  Voluntari – Otelul

  28 August

• 
  Lokomotiv M – Dynamo M

  29 August

• 
  Akhmat – Krylia Sovetov

  29 August

• 
  Krasnodar – Rostov

  29 August

• 
  Fakel – Zenit

  29 August

• 
  Akron – CSKA

  28 August

• 
  Real Sociedad – Espanyol

  29 August

• 
  Levante – Real Betis

  29 August

• 
  Alaves – Villarreal

  28 August

• 
  Racing – Elche

  28 August

• 
  Genclerbirligi – BB

  28 August

• 
  Shakhtar – Polissya

  29 August

• 
  Livyi Bereh – Karpaty

  29 August

• 
  Kudrivka – Epitsentr

  29 August

• 
  Kolos – Obolon

  28 August

• 
  Atletico – Instituto

  28 August